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Did you know the skull of the famous Italian poet Francesco Petrarca is missing?

The skull of this great poet has been swapped with that of an unknown female

Francesco Patrarca was a Renaissance scholar whose influence reached far beyond his time. In 2003, his tomb was opened so the cranium could be used to generate a computerized model of Patrarca’s face to commemorate his 700th birthday. Unfortunately these plans never came to fruition as the skull was in fragments and there were suspicions that it actually belonged to a different person.

Francesco Petrarca was a famous Italian poet and scholar from the Renaissance Period. He’s often known as the “Father of Humanism”, who despite having a career in the church believed that worldly achievements should not interfere with having an authentic relationship with God. His most famous works are Italian poetry, including the Canzoniere (“Songbook”) and the Trionfi (“Triumphs”), however most of his writing was done in Latin. The “Songbook” is a collection of poems inspired by his forbidden (and unreciprocated) love for a married woman, Laura, and intense grief upon her early death during the plague. It is said that Petrarca left priesthood at the sight of Laura.

Statue of Francesco Petrarca in Florence
Statue of Francesco Petrarca in Florence

Petrarca loved to travel and was known as “the first tourist”, because he often traveled just for pleasure. During his travels he collected crumbling Latin manuscripts, becoming one of the main recoverers of knowledge from Rome and Greece. In one of his recreational expeditions, he climbed to the summit of Mount Ventoux and his letters describing his aesthetic gratification in the scenery are still cited in books and journals dedicated to mountaineering.

Although he never married, Petrarca had two children, a son, Giovanni, and a daughter, Francesca, both of whom he later legitimized. Giovanni died of the plague and Petrarca spent his final years with his daughter in the small town of Arquà near Padua in religious contemplation. He died in 1374, one day short of his 70th birthday.

Just over 250 years after Petrarca’s death, a drunken friar and four accomplices broke into his tomb and stole some of Petrarca’s remains. Even though the culprits were later arrested, the missing bones were never recovered. When his tomb was reopened centuries later in 2003, researchers were fairly certain that the reassembled skeleton belonged to Petrarca, since it bore evidence of injuries known to have affected Petrarca during his lifetime. However, the skull was discovered in fragments, and it was speculated that it belonged to a different individual. DNA analyses were conducted to address the possibility that the skull was swapped during the robbery in 1630.

Scientists generated mitochondrial DNA profiles from a tooth and a rib collected from the tomb to determine if the skull and remaining skeleton in Petrarca’s tomb actually belonged to the same person. Mitochondrial DNA (mtDNA) has a high copy number (hundreds of copies per cell), rapid evolution rate and strict maternal inheritance, making it the most suitable and informative DNA type for the analysis of ancient human remains. Three regions of the mtDNA can be analyzed – two hypervariable regions (HVR1 and HVR2) and the coding region.

DNA Maternal Ancestry Test box

DNA Maternal Ancestry Test

When mtDNA profiles of the HVR1 region from each sample (tooth and rib) were compared, researchers identified four differences between the two samples, meaning that there is no possibility that they originated from the same person. Further analyses revealed that the rib belonged to a male (as expected for Petrarca), but the tooth actually belonged to a female. Furthermore, radiocarbon dating of the skull showed that is was actually two centuries older than the remainder of the skeleton.

The discovery that the skull in Petrarca’s tomb didn’t actually belong to this famous poet somewhat upset the plans made to commemorate his 700th birthday. While DNA analyses confirmed that a skull swap did occur at some point in history, the actual date of this swap cannot be confirmed, although it most likely occurred during the grave robbery in 1630. Petrarca’s own skull remains missing and is unlikely to be recovered.

The DNA tests conducted in this study have defined the mtDNA profile of Francesco Petrarca. If you have taken the DNA Maternal Ancestry Test, you can compare your mtDNA against Petrarca to see if you may have descended from the same maternal lineage as this famous Italian poet.


Caramelli D et al. (2007) Genetic analysis of the skeletal remains attributed to Francesco Petrarca. Forensic Sci Int. 173(1):36-40.

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